Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis

H Nozawa, C Chiu, D Hanahan - Proceedings of the …, 2006 - National Acad Sciences
Matrix metalloprotease type 9 (MMP-9) has been functionally implicated in VEGF activation,
the induction and maintenance of chronic angiogenesis, and early stage tumor growth in a …

Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

N Tanaka, M Ishihara, MS Lamphier, H Nozawa… - Nature, 1996 - nature.com
NORMALLY growing cells promptly cease DNA synthesis when exposed to genotoxic stresses,
such as radiation, and this cell-cycle arrest prevents the accumulation of mutations 1,2 . …

Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response

…, S Tazzyman, N Erez, YY Chen, C Murdoch, H Nozawa… - Neoplasia, 2008 - Elsevier
Previous studies in the K14-HPV/E 2 mouse model of cervical carcinogenesis demonstrated
that infiltrating macrophages are the major source of matrix metalloproteinase 9 (MMP-9), a …

Type I interferons are essential mediators of apoptotic death in virally infected cells

N Tanaka, M Sato, MS Lamphier, H Nozawa… - Genes to …, 1998 - Wiley Online Library
Background The interferons (IFNs) have been extensively studied in the context of host
defence against viral infection. In the established model of IFN action, virally infected cells …

[HTML][HTML] Level of arterial ligation in sigmoid colon and rectal cancer surgery

…, T Tanaka, T Kiyomatsu, K Hata, H Nozawa… - World journal of surgical …, 2016 - Springer
Background Curative resection of sigmoid colon and rectal cancer includes “high tie” of the
inferior mesenteric artery (IMA). However, IMA ligation compromises blood flow to the …

[HTML][HTML] Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growth factor …

CW Chiu, H Nozawa, D Hanahan - Journal of Clinical Oncology, 2010 - ncbi.nlm.nih.gov
Purpose Pancreatic neuroendocrine tumors (PNETs), although rare, often metastasize,
such that surgery, the only potentially curative therapy, is not possible. There is no effective …

Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53

H Nozawa, E Oda, K Nakao, M Ishihara… - Genes & …, 1999 - genesdev.cshlp.org
The transcription factor IRF-1 has been implicated in tumor suppression: IRF-1 suppresses
cell transformation and mediates apoptosis in vitro. Here we show that the loss of IRF-1 …

Elevated neutrophil to lymphocyte ratio predicts poor prognosis in advanced colorectal cancer patients receiving oxaliplatin-based chemotherapy

M Kaneko, H Nozawa, K Sasaki, K Hongo, M Hiyoshi… - Oncology, 2012 - karger.com
Background: The aim of this study was to assess whether the neutrophil to lymphocyte ratio (NLR)
and other laboratory markers may predict the prognosis of advanced colorectal cancer …

A microRNA signature associated with metastasis of T1 colorectal cancers to lymph nodes

T Ozawa, R Kandimalla, F Gao, H Nozawa, K Hata… - Gastroenterology, 2018 - Elsevier
Most T1 colorectal cancers treated by radical surgery can now be cured by endoscopic
submucosal dissection. Although 70%−80% of T1 colorectal cancers are classified as high risk, <…

Functionally inactivating point mutation in the tumor‐suppressor IRF‐1 gene identified in human gastric cancer

H Nozawa, E Oda, S Ueda, G Tamura… - … journal of cancer, 1998 - Wiley Online Library
Loss of heterozygosity (LOH) observed in human tumors strongly suggests the existence of (a)
tumor‐suppressor gene(s) at the concerned locus. A series of studies has revealed that …