User profiles for EMANUEL F. PETRICOIN
Emanuel PetricoinGeorge Mason University Verified email at gmu.edu Cited by 54445 |
Use of proteomic patterns in serum to identify ovarian cancer
EF Petricoin, AM Ardekani, BA Hitt, PJ Levine… - The lancet, 2002 - thelancet.com
Background New technologies for the detection of early-stage ovarian cancer are urgently
needed. Pathological changes within an organ might be reflected in proteomic patterns in …
needed. Pathological changes within an organ might be reflected in proteomic patterns in …
[PDF][PDF] Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
SR Hingorani, EF Petricoin, A Maitra, V Rajapakse… - Cancer cell, 2003 - cell.com
To evaluate the role of oncogenic RAS mutations in pancreatic tumorigenesis, we directed
endogenous expression of KRAS G12D to progenitor cells of the mouse pancreas. We find …
endogenous expression of KRAS G12D to progenitor cells of the mouse pancreas. We find …
Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front
…, MR Emmert-Buck, MJ Roth, EF Petricoin III… - Oncogene, 2001 - nature.com
Protein arrays are described for screening of molecular markers and pathway targets in patient
matched human tissue during disease progression. In contrast to previous protein arrays …
matched human tissue during disease progression. In contrast to previous protein arrays …
Proteomic applications for the early detection of cancer
JD Wulfkuhle, LA Liotta, EF Petricoin - Nature reviews cancer, 2003 - nature.com
The ability of physicians to effectively treat and cure cancer is directly dependent on their ability
to detect cancers at their earliest stages. Proteomic analyses of early-stage cancers have …
to detect cancers at their earliest stages. Proteomic analyses of early-stage cancers have …
Serum proteomic patterns for detection of prostate cancer
EF Petricoin III, DK Ornstein… - Journal of the …, 2002 - academic.oup.com
Pathologic states within the prostate may be reflected by changes in serum proteomic patterns.
To test this hypothesis, we analyzed serum proteomic mass spectra with a bioinformatics …
To test this hypothesis, we analyzed serum proteomic mass spectra with a bioinformatics …
Laser-capture microdissection
…, W Zhou, G Coukos, DH Geho, EF Petricoin III… - Nature protocols, 2006 - nature.com
Deciphering the cellular and molecular interactions that drive disease within the tissue
microenvironment holds promise for discovering drug targets of the future. In order to recapitulate …
microenvironment holds promise for discovering drug targets of the future. In order to recapitulate …
Clinical proteomics: translating benchside promise into bedside reality
EF Petricoin, KC Zoon, EC Kohn, JC Barrett… - Nature reviews Drug …, 2002 - nature.com
The ultimate goal of proteomics is to characterize the information flow through protein
networks. This information can be a cause, or a consequence, of disease processes. Clinical …
networks. This information can be a cause, or a consequence, of disease processes. Clinical …
[HTML][HTML] 2D differential in-gel electrophoresis for the identification of esophageal scans cell cancer-specific protein markers
…, MR Emmert-Buck, LA Liotta, EF Petricoin… - Molecular & Cellular …, 2002 - ASBMB
The reproducibility of conventional two-dimensional (2D) gel electrophoresis can be improved
using differential in-gel electrophoresis (DIGE), a new emerging technology for proteomic …
using differential in-gel electrophoresis (DIGE), a new emerging technology for proteomic …
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer
…, AK Witkiewicz, ES Knudsen, EF Petricoin III… - Nature medicine, 2019 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is characterized by KRAS- and autophagy-dependent
tumorigenic growth, but the role of KRAS in supporting autophagy has not been …
tumorigenic growth, but the role of KRAS in supporting autophagy has not been …
[PDF][PDF] Protein microarrays: meeting analytical challenges for clinical applications
…, PJ Munson, L Young, J Wulfkuhle, EF Petricoin - Cancer cell, 2003 - cell.com
Protein microarrays, one emerging class of proteomic technologies, have broad applications
for discovery and quantitative analysis. A rapidly expanding use of this technology is the …
for discovery and quantitative analysis. A rapidly expanding use of this technology is the …