Background Cancers result from the accumulation of somatic mutations, and their properties
are thought to reflect the sum of these mutations. However, little is known about the effect of …

It was previously shown that the NF-κB pathway is downstream of oncogenic Notch1 in T cell
acute lymphoblastic leukemia (T-ALL). Here, we visualize Notch-induced NF-κB activation …

Although approximately 95% of patients with polycythemia vera (PV) harbor the V617F
mutation in JAK2 exon 14, several mutations in exon 12 have been described in the remaining …

Criteria of response and definition of resistance and intolerance to hydroxyurea (HU) in
polycythemia vera (PV) were proposed by the European LeukemiaNet (ELN). Such criteria were …

In this report we analyse the presenting features of a series of patients diagnosed with
Waldenström macroglobulinaemia (WM) in Spain over the last 10 years. Criteria for diagnosis …

A widely accepted definition of resistance or intolerance to hydroxyurea (HU) in patients
with essential thrombocythemia (ET) is lacking. An international working group (WG) was …

Introduction: Hematological disorders account for about 1.3% of all causes of acute stroke.
This systematized review presents updated information on the implications of this category of …

Standardized criteria of response to treatment and a unified definition of resistance/intolerance
to hydroxycarbamide (HC) in essential thrombocythaemia (ET) have been proposed by …

Therapeutic options for patients with polycythemia vera (PV) and essential thrombocythemia
(ET) resistant or intolerant to hydroxyurea are limited. Busulfan is effective as first-line …

The clinical significance of resistance/intolerance to hydroxycarbamide ( HC ) was assessed
in a series of 890 patients with polycythaemia vera ( PV ). Resistance/intolerance to HC was …