Somatic gene transfer is a promising therapeutic strategy, but it may also evoke new types of
side effects related to genetic damage or transgene activity. Retroviral vectors, the best tool …

SARS-CoV-2 vaccine ChAdOx1 nCoV-19 (AstraZeneca) causes a thromboembolic
complication termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Using …

Recent conceptual and technical improvements have resulted in clinically meaningful levels
of gene transfer into repopulating hematopoietic stem cells. At the same time, evidence is …

Hematotoxicity represents a frequent chimeric antigen receptor (CAR) T-cell–related adverse
event and remains poorly understood. In this multicenter analysis, we studied patterns of …

Functional gene analysis requires the possibility of overexpression, as well as downregulation
of one, or ideally several, potentially interacting genes. Lentiviral vectors are well suited …

Increasing evidence reveals that random insertion of gene transfer vectors into the genome
of repopulating hematopoietic cells may alter their fate in vivo. Although most insertional …

Gene marking with replication-defective retroviral vectors has been used for more than 20
years to track the in vivo fate of cell clones. We demonstrate that retroviral integrations …

Recently, unusual forms of leukemias have developed as complications following retroviral
transfer of potentially therapeutic genes into hematopoietic cells. A crucial component in the …

We evaluated toxicity, engraftment, chimerism, graft-versus-host disease (GVHD), and response
to a dose-reduced allograft after cytoreductive autografting in 17 patients with advanced …

Acute myeloid leukemia (AML) represents a clonal disease of hematopoietic progenitors
characterized by acquired heterogenous genetic changes that alter normal mechanisms of …