A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions
Tumor cell invasion is a process regulated by integrins, matrix-degrading enzymes, and
interactions with host tissue stromal cells. The ADAM family of proteins plays an important role in …
interactions with host tissue stromal cells. The ADAM family of proteins plays an important role in …
[PDF][PDF] Down‐regulation of connective tissue growth factor by inhibition of transforming growth factor β blocks the tumor–stroma cross‐talk and tumor progression in …
A Mazzocca, E Fransvea, F Dituri, L Lupo… - …, 2010 - Wiley Online Library
Tumor–stroma interactions in hepatocellular carcinoma (HCC) are of key importance to
tumor progression. In this study, we show that HCC invasive cells produce high levels of …
tumor progression. In this study, we show that HCC invasive cells produce high levels of …
Overexpression of Bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans
…, L Monitillo, S Cannito, I Petrai, A Mazzocca… - Gut, 2006 - gut.bmj.com
Background and aims: Myofibroblast-like cells, originating from activation of hepatic stellate
cells (HSC/MFs), play a key role in liver fibrosis, a potentially reversible process that may rely …
cells (HSC/MFs), play a key role in liver fibrosis, a potentially reversible process that may rely …
[PDF][PDF] T (14; 18) translocation in chronic hepatitis C virus infection
…, F Giannelli, ME Marrocchi, A Mazzocca… - …, 2000 - Wiley Online Library
Pathogenic mechanisms of B‐cell lymphoproliferative disorders in chronic hepatitis C virus (HCV)
infection are unclear. We studied t(14;18) translocation by polymerase chain reaction …
infection are unclear. We studied t(14;18) translocation by polymerase chain reaction …
[PDF][PDF] Targeting transforming growth factor (TGF)‐βRI inhibits activation of β1 integrin and blocks vascular invasion in hepatocellular carcinoma
E Fransvea, A Mazzocca, S Antonaci, G Giannelli - Hepatology, 2009 - Wiley Online Library
Vascular invasion is one of the major negative prognostic factors in patients with hepatocellular
carcinoma (HCC), leading to cancer recurrence. To invade, HCC cells must penetrate …
carcinoma (HCC), leading to cancer recurrence. To invade, HCC cells must penetrate …
[HTML][HTML] Obesity, nonalcoholic fatty liver disease and adipocytokines network in promotion of cancer
R Divella, A Mazzocca, A Daniele… - … journal of biological …, 2019 - ncbi.nlm.nih.gov
Western populations are becoming increasingly sedentary and the incidence of nonalcoholic
fatty liver disease (NAFLD) is increasing and becoming one of the most common causes of …
fatty liver disease (NAFLD) is increasing and becoming one of the most common causes of …
[PDF][PDF] Tumor‐secreted lysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts
A Mazzocca, F Dituri, L Lupo, M Quaranta… - …, 2011 - Wiley Online Library
Hepatocellular carcinoma (HCC) occurs in fibrotic liver as a consequence of underlying
cirrhosis. The goal of this study was to investigate how the interaction between HCC cells and …
cirrhosis. The goal of this study was to investigate how the interaction between HCC cells and …
[PDF][PDF] Inhibition of transforming growth factor β receptor I kinase blocks hepatocellular carcinoma growth through neo‐angiogenesis regulation
A Mazzocca, E Fransvea, G Lavezzari, S Antonaci… - …, 2009 - Wiley Online Library
Curative therapies for patients with hepatocellular carcinoma (HCC) are mainly invasive,
and with the exception of sorafenib, no medical treatments are available for advanced or …
and with the exception of sorafenib, no medical treatments are available for advanced or …
[HTML][HTML] Differential inhibition of the TGF-β signaling pathway in HCC cells using the small molecule inhibitor LY2157299 and the D10 monoclonal antibody against …
F Dituri, A Mazzocca, FJ Peidrò, P Papappicco… - PloS one, 2013 - journals.plos.org
We investigated blocking the TGF-β signaling pathway in HCC using two small molecule
inhibitors (LY2157299, LY2109761) and a neutralizing humanized antibody (D10) against TGF-…
inhibitors (LY2157299, LY2109761) and a neutralizing humanized antibody (D10) against TGF-…
[HTML][HTML] Binding of hepatitis C virus envelope protein E2 to CD81 up-regulates matrix metalloproteinase-2 in human hepatic stellate cells
A Mazzocca, SC Sciammetta, V Carloni, L Cosmi… - Journal of Biological …, 2005 - ASBMB
The hepatitis C virus (HCV) envelope E2 glycoprotein is a key molecule regulating the interaction
of HCV with cell surface proteins. E2 binds the major extracellular loop of human CD81…
of HCV with cell surface proteins. E2 binds the major extracellular loop of human CD81…