[HTML][HTML] Dendritic cell-based vaccination in metastatic melanoma patients: phase II clinical trial
…, H Miyata, T Ashizawa, A Iizuka… - Oncology …, 2012 - spandidos-publications.com
Metastatic and chemoresistant melanoma can be a good target of immunotherapy because
it is an intractable cancer with a very poor prognosis. Previously, we tested a dendritic cell (…
it is an intractable cancer with a very poor prognosis. Previously, we tested a dendritic cell (…
[HTML][HTML] α-type-1 polarized dendritic cell-based vaccination in recurrent high-grade glioma: a phase I clinical trial
Y Akiyama, C Oshita, A Kume, A Iizuka, H Miyata… - BMC cancer, 2012 - Springer
Background High-grade gliomas including glioblastoma multiforme (GBM) are among the
most malignant and aggressive of tumors, and have a very poor prognosis despite a …
most malignant and aggressive of tumors, and have a very poor prognosis despite a …
Lentivector‐mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia
T Torashima, C Koyama, A Iizuka, K Mitsumura… - EMBO …, 2008 - embopress.org
Polyglutamine disorders are inherited neurodegenerative diseases caused by the accumulation
of expanded polyglutamine protein (polyQ). Previously, we identified a new guanosine …
of expanded polyglutamine protein (polyQ). Previously, we identified a new guanosine …
[HTML][HTML] Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma
T Ashizawa, H Miyata, A Iizuka… - International …, 2013 - spandidos-publications.com
Signal transducer and activator of transcription (STAT) 3, a member of a family of DNA-binding
molecules, is a potential target in the treatment of cancer. The highly phosphorylated …
molecules, is a potential target in the treatment of cancer. The highly phosphorylated …
Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells
…, TJ Lu, JB Wu, CH Wu, TC Yang, A Iizuka… - Food and chemical …, 2009 - Elsevier
The MDM2 proto-oncogene is overexpressed in many human tumors. Although MDM2
inhibits tumor-suppressor function of p53, there exists a p53-independent role for MDM2 in …
inhibits tumor-suppressor function of p53, there exists a p53-independent role for MDM2 in …
Antitumor effect of programmed death-1 (PD-1) blockade in humanized the NOG-MHC double knockout mouse
T Ashizawa, A Iizuka, C Nonomura, R Kondou… - Clinical Cancer …, 2017 - AACR
Purpose: Humanized mouse models using NOD/Shi-scid-IL2rγ null (NOG) and NOD/LtSz-scid
IL2rγ null (NSG) mouse are associated with several limitations, such as long incubation …
IL2rγ null (NSG) mouse are associated with several limitations, such as long incubation …
Mutant PKCγ in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo
…, T Seki, H Goenawan, T Irie, A Iizuka… - Journal of …, 2011 - Soc Neuroscience
Cerebellar Purkinje cells (PCs) express a large amount of the γ isoform of protein kinase C (PKCγ)
and a modest level of PKCα. The PKCγ is involved in the pruning of climbing fiber (CF…
and a modest level of PKCα. The PKCγ is involved in the pruning of climbing fiber (CF…
Evaluation of Rhubarb using antioxidative activity as an index of pharmacological usefulness
A Iizuka, OT Iijima, K Kondo, H Itakura, F Yoshie… - Journal of …, 2004 - Elsevier
We attempted to estimate the pharmacological activity by measuring the concentrations of a
composition ingredient using a multivariate statistical analysis method. Medicinal herb of …
composition ingredient using a multivariate statistical analysis method. Medicinal herb of …
Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar …
A Konno, AN Shuvaev, N Miyake, K Miyake, A Iizuka… - The Cerebellum, 2014 - Springer
Spinocerebellar ataxia type 3 (SCA3) is caused by the abnormal expansion of CAG repeats
within the ataxin-3 gene. Previously, we generated transgenic mice (SCA3 mice) that …
within the ataxin-3 gene. Previously, we generated transgenic mice (SCA3 mice) that …
Identification of melanoma antigens using a Serological Proteome Approach (SERPA)
A Suzuki, A Iizuka, M Komiyama… - Cancer genomics & …, 2010 - cgp.iiarjournals.org
Background: Melanoma is an intractable cancer with a poor prognosis and increasing prevalence
worldwide. Specific biomarkers for early diagnosis have yet to be found. Materials and …
worldwide. Specific biomarkers for early diagnosis have yet to be found. Materials and …