Adipocytic tumours are among the most common mesenchymal neoplasms, and constitute a clinically, biologically and pathologically diverse group. Their wide histological spectrum and frequent morphological overlap have made classification and diagnosis challenging, with accurate classification being critical because of the considerable differences in prognosis and management between morphologically overlapping neoplasms. Ongoing advances in molecular genetics have aided significantly to our understanding of these neoplasms, with continuing evolution in classification. This review summarises the new developments in benign and malignant adipocytic neoplasms, with discussion of new entities and genetic findings, updates on the clinical and morphological spectrum, and the use of diagnostic immunohistochemistry and molecular markers in the differential diagnosis.
Keywords: CDK4; MDM2; PLAG1; RB1; atypical spindle cell lipomatous tumour; chromosome 12q; chromosome 12q13-15; chromosome 13q; dedifferentiated; genetics; lipoblastoma; liposarcoma; myxoid pleomorphic; pathology; pleomorphic lipoma; sarcoma; well-differentiated.
© 2021 John Wiley & Sons Ltd.