miR-10a controls glioma migration and invasion through regulating epithelial-mesenchymal transition via EphA8

FEBS Lett. 2015 Mar 12;589(6):756-65. doi: 10.1016/j.febslet.2015.02.005. Epub 2015 Feb 12.

Abstract

MicroRNAs (miRNAs) play a critical role in the development of cancers. However, the role of miRNAs in glioma is still poorly understood. In this study, we demonstrate that microRNA-10a (miR-10a) promotes cell migration and invasion by negatively regulating the expression of Eph tyrosine kinase receptor A8 (EphA8). Ectopic expression of EphA8 counteracts the promotion of migration and invasion induced by miR-10a. We further demonstrate that miR-10a and EphA8 regulate epithelial-mesenchymal transition (EMT) to affect cell migration and invasion. Collectively, we unveil a branch of the miR-10a/EphA8 pathway that regulates the progression of glioma.

Keywords: Eph tyrosine kinase receptor A8; Epithelial–mesenchymal transition; Glioma; Invasion; MicroRNAs; Migration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Untranslated Regions
  • Base Sequence
  • Binding Sites
  • Cell Line, Tumor
  • Cell Movement*
  • Epithelial-Mesenchymal Transition*
  • Gene Expression
  • Gene Expression Regulation, Neoplastic
  • Glioma / pathology*
  • Humans
  • MicroRNAs / physiology*
  • Molecular Sequence Data
  • Neoplasm Invasiveness
  • RNA Interference
  • Receptor, EphA8 / genetics*
  • Receptor, EphA8 / metabolism
  • Up-Regulation

Substances

  • 3' Untranslated Regions
  • MIRN10 microRNA, human
  • MicroRNAs
  • Receptor, EphA8