Follicular lesions of the thyroid

Aarti Mathur; Matthew T Olson; Martha A Zeiger

doi:10.1016/j.suc.2014.02.005

Follicular lesions of the thyroid

Surg Clin North Am. 2014 Jun;94(3):499-513. doi: 10.1016/j.suc.2014.02.005. Epub 2014 Apr 3.

Authors

Aarti Mathur¹, Matthew T Olson², Martha A Zeiger³

Affiliations

¹ Department of Surgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA.
² Department of Pathology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA.
³ Department of Surgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA. Electronic address: mzeiger@jhmi.edu.

PMID: 24857573
DOI: 10.1016/j.suc.2014.02.005

Abstract

Follicular lesions of the thyroid encompass a wide spectrum of diseases with clinicopathologic overlap, including benign follicular adenoma, malignant follicular carcinoma, and follicular variant of papillary cancer. This review addresses the clinical presentation, preoperative diagnosis in the era of molecular markers, pathologic diagnosis, treatment, and prognosis of follicular lesions, taking into account the frequent controversy about definitive histologic diagnoses.

Keywords: Cancer; Follicular; Neoplasms; Thyroid.

Publication types

Review

MeSH terms

Adenocarcinoma, Follicular / diagnosis*
Adenocarcinoma, Follicular / metabolism
Adenoma / diagnosis*
Biomarkers, Tumor / analysis*
Biopsy, Fine-Needle
Diagnosis, Differential
Humans
Neoplasm Staging*
Prognosis
Thyroid Neoplasms / diagnosis*
Thyroid Neoplasms / metabolism

Substances

Biomarkers, Tumor