O-GlcNAc signaling in cancer metabolism and epigenetics

Jay Prakash Singh; Kaisi Zhang; Jing Wu; Xiaoyong Yang

doi:10.1016/j.canlet.2014.04.014

O-GlcNAc signaling in cancer metabolism and epigenetics

Cancer Lett. 2015 Jan 28;356(2 Pt A):244-50. doi: 10.1016/j.canlet.2014.04.014. Epub 2014 Apr 24.

Authors

Jay Prakash Singh¹, Kaisi Zhang², Jing Wu³, Xiaoyong Yang⁴

Affiliations

¹ Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA; Section of Comparative Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA.
² Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA; Section of Comparative Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA; Department of Cellular & Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA.
³ Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA; Section of Comparative Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA; School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China.
⁴ Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA; Section of Comparative Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA; Department of Cellular & Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA. Electronic address: xiaoyong.yang@yale.edu.

Abstract

The covalent attachment of β-D-N-acetylglucosamine monosaccharides (O-GlcNAc) to serine/threonine residues of nuclear and cytoplasmic proteins is a major regulatory mechanism in cell physiology. Aberrant O-GlcNAc modification of signaling proteins, metabolic enzymes, and transcriptional and epigenetic regulators has been implicated in cancer. Relentless growth of cancer cells requires metabolic reprogramming that is intertwined with changes in the epigenetic landscape. This review highlights the emerging role of protein O-GlcNAcylation at the interface of cancer metabolism and epigenetics.

Keywords: Cancer metabolism; Epigenetics; O-GlcNAc; Posttranslational modifications.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Acetylglucosamine / metabolism*
Antigens, Neoplasm / metabolism
Cell Proliferation
Energy Metabolism / genetics*
Epigenesis, Genetic*
Glycosylation
Histone Acetyltransferases / metabolism
Histones / metabolism
Humans
Hyaluronoglucosaminidase / metabolism
N-Acetylglucosaminyltransferases / metabolism
Neoplasms / genetics*
Neoplasms / metabolism*
Protein Processing, Post-Translational / physiology*
Serine / metabolism
Signal Transduction / genetics
Threonine / metabolism
Transcription Factors / metabolism
Transcription, Genetic / genetics
Transcriptional Activation

Substances

Antigens, Neoplasm
Histones
Transcription Factors
Threonine
Serine
Histone Acetyltransferases
N-Acetylglucosaminyltransferases
UDP-N-acetylglucosamine-peptide beta-N-acetylglucosaminyltransferase
OGA protein, human
Hyaluronoglucosaminidase
Acetylglucosamine

Abstract

Publication types

MeSH terms

Substances

Grants and funding