Gene regulatory networks and transcriptional mechanisms that control myogenesis

Margaret Buckingham; Peter W J Rigby

doi:10.1016/j.devcel.2013.12.020

Gene regulatory networks and transcriptional mechanisms that control myogenesis

Dev Cell. 2014 Feb 10;28(3):225-38. doi: 10.1016/j.devcel.2013.12.020.

Authors

Margaret Buckingham¹, Peter W J Rigby²

Affiliations

¹ CNRS URA 2578, Department of Developmental and Stem Cell Biology, Institut Pasteur, 75015 Paris, France. Electronic address: margaret.buckingham@pasteur.fr.
² Division of Cancer Biology, Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, UK. Electronic address: peter.rigby@icr.ac.uk.

PMID: 24525185
DOI: 10.1016/j.devcel.2013.12.020

Abstract

We discuss the upstream regulators of myogenesis that lead to the activation of myogenic determination genes and subsequent differentiation, focusing on the mouse model. Key upstream genes, such as Pax3 and Pax7, Six1 and Six4, or Pitx2, participate in gene regulatory networks at different sites of skeletal muscle formation. MicroRNAs also intervene, with emerging evidence for the role of other noncoding RNAs. Myogenic determination and subsequent differentiation depend on members of the MyoD family. We discuss new insights into mechanisms underlying the transcriptional activity of these factors.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Gene Expression Regulation, Developmental*
Gene Regulatory Networks*
Humans
Muscle Development / genetics*
Transcription Factors
Transcription, Genetic*

Substances

Transcription Factors