Abstract
The function of vascular endothelial growth factor (VEGF) in cancer is not limited to angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells, and this signalling contributes to key aspects of tumorigenesis, including the function of cancer stem cells and tumour initiation. In addition to VEGF receptor tyrosine kinases, the neuropilins are crucial for mediating the effects of VEGF on tumour cells, primarily because of their ability to regulate the function and the trafficking of growth factor receptors and integrins. This has important implications for our understanding of tumour biology and for the development of more effective therapeutic approaches.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use
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Autocrine Communication
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Capillary Permeability
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Humans
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Molecular Targeted Therapy
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Neoplasms / drug therapy
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Neoplasms / metabolism*
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Neoplasms / pathology
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Neoplastic Stem Cells / metabolism
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Neuropilins / physiology
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Receptors, Vascular Endothelial Growth Factor / metabolism
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Signal Transduction
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Tumor Microenvironment
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Vascular Endothelial Growth Factor A / physiology*
Substances
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Antineoplastic Agents
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Neuropilins
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VEGFA protein, human
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Vascular Endothelial Growth Factor A
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Receptors, Vascular Endothelial Growth Factor