Abstract
FoxP1 has been reported to be expressed in several types of human malignant tumors, and has been associated with metastasis and patient prognosis. Quantitative real-time polymerase chain reaction (PCR) and immunohistochemical analysis with tissue microarray were used to characterize the expression of FoxP1 in non-small cell lung cancer (NSCLC). It was revealed that the expression of FoxP1 messenger RNA (mRNA) and protein was significantly higher in NSCLC tissue than in corresponding peritumoral tissue (P = .013 and P < .001, respectively). The expression of FoxP1 protein in NSCLC was related to gender, histologic type, and 5-year survival rate (all P < .05). Finally, we evaluated the prognostic significance of the expression of FoxP1 in a group of patients. Kaplan-Meier survival and Cox regression analyses showed that low expression of FoxP1 (P < .001) and later stage grouping by TNM (P = .022) were independent factors predicting poor prognosis for NSCLC.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / chemistry
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Adenocarcinoma / mortality
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Adenocarcinoma / pathology
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Adenocarcinoma / secondary
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Adult
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Aged
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Aged, 80 and over
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Base Sequence
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Biomarkers, Tumor / analysis*
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Carcinoma, Non-Small-Cell Lung / chemistry*
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Carcinoma, Non-Small-Cell Lung / genetics
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Carcinoma, Non-Small-Cell Lung / mortality*
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Carcinoma, Non-Small-Cell Lung / pathology
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Carcinoma, Non-Small-Cell Lung / secondary
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Carcinoma, Squamous Cell / chemistry
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Carcinoma, Squamous Cell / mortality
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Carcinoma, Squamous Cell / pathology
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Carcinoma, Squamous Cell / secondary
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Female
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Forkhead Transcription Factors / analysis*
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Forkhead Transcription Factors / genetics
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Humans
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Immunohistochemistry
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Lung Neoplasms / chemistry*
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Lung Neoplasms / genetics
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Lung Neoplasms / mortality*
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Lung Neoplasms / pathology
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Male
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Middle Aged
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Neoplasm Staging
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Prognosis
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Protein Array Analysis
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RNA, Messenger / analysis
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Repressor Proteins / analysis*
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Repressor Proteins / genetics
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Survival Rate
Substances
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Biomarkers, Tumor
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FOXP1 protein, human
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Forkhead Transcription Factors
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RNA, Messenger
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Repressor Proteins