Abstract
The concept of having an 'intrinsic subtype,' or a molecular taxonomy, lets us clearly recognize that breast cancers have characteristically different patterns of gene expression, thus giving newfound significance to morphological taxonomy. In this review, the concept of the 'intrinsic subtype' is discussed, research questions are introduced to refine the significance of morphological taxonomy, and a corresponding example is presented between microarray analysis and 'immunohistochemical subtype,' or histological taxonomy.
© 2012 The Author. Pathology International © 2012 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenocarcinoma / classification
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Adenocarcinoma / genetics*
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Adenocarcinoma / pathology*
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Apocrine Glands / pathology
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / metabolism
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Breast Neoplasms / classification
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Breast Neoplasms / genetics*
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Breast Neoplasms / pathology*
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Carcinoma / classification
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Carcinoma / genetics
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Carcinoma / pathology
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Carcinoma, Adenoid Cystic / classification
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Carcinoma, Adenoid Cystic / genetics
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Carcinoma, Adenoid Cystic / pathology
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Carcinoma, Ductal, Breast / classification
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Carcinoma, Ductal, Breast / genetics
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Carcinoma, Ductal, Breast / pathology
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Carcinoma, Intraductal, Noninfiltrating / classification
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Carcinoma, Intraductal, Noninfiltrating / genetics
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Carcinoma, Intraductal, Noninfiltrating / pathology
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Carcinoma, Lobular / classification
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Carcinoma, Lobular / genetics
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Carcinoma, Lobular / pathology
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Carcinoma, Medullary / classification
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Carcinoma, Medullary / genetics
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Carcinoma, Medullary / pathology
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Cell Line, Tumor
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Female
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Gene Expression Profiling
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Gene Expression Regulation, Neoplastic*
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Humans
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Oligonucleotide Array Sequence Analysis
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Systems Biology
Supplementary concepts
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Secretory breast carcinoma