Abstract
BK polyomavirus (BKPyV) is a small double-stranded DNA virus that is an emerging pathogen in immunocompromised individuals. BKPyV is widespread in the general population, but primarily causes disease when immune suppression leads to reactivation of latent virus. Polyomavirus-associated nephropathy and hemorrhagic cystitis in renal and bone marrow transplant patients, respectively, are the most common diseases associated with BKPyV reactivation and lytic infection. In this review, we discuss the clinical relevance, effects on the host, virus life cycle, and current treatment protocols.
Copyright © 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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BK Virus / pathogenicity*
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Bone Marrow Transplantation / adverse effects
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Communicable Diseases, Emerging / epidemiology*
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Communicable Diseases, Emerging / pathology
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Communicable Diseases, Emerging / therapy
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Communicable Diseases, Emerging / virology
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Humans
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Immunocompromised Host
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Kidney Transplantation / adverse effects
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Polyomavirus Infections / epidemiology*
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Polyomavirus Infections / pathology
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Polyomavirus Infections / therapy
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Polyomavirus Infections / virology
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Tumor Virus Infections / epidemiology*
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Tumor Virus Infections / pathology
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Tumor Virus Infections / therapy
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Tumor Virus Infections / virology