The controversial role of placental growth factor in tumor growth

Domenico Ribatti

doi:10.1016/j.canlet.2011.02.043

The controversial role of placental growth factor in tumor growth

Cancer Lett. 2011 Aug 1;307(1):1-5. doi: 10.1016/j.canlet.2011.02.043. Epub 2011 Mar 22.

Author

Domenico Ribatti¹

Affiliation

¹ Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy. Electronic address: ribatti@anatomia.uniba.it.

PMID: 21429661
DOI: 10.1016/j.canlet.2011.02.043

Abstract

The significance of placental growth factor (PlGF) in tumor growth is still a matter of debate. Depending on the model, PlGF overexpression has been shown to result in tumor growth promotion or inhibition. This review article summarizes the most relevant literature data concerning this still unsolved important question.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Genes, Tumor Suppressor
Humans
Neoplasms / metabolism
Neoplasms / pathology*
Oncogenes
Placenta Growth Factor
Pregnancy Proteins / physiology*

Substances

PGF protein, human
Pregnancy Proteins
Placenta Growth Factor