Abstract
Pigment epithelium-derived factor (PEDF), one of the non-inhibitory serpines, is widely expressed throughout the body. Although PEDF was initially identified as a neuronal differentiation factor, more attention has been paid to its anti-angiogenic activity. Additionally, recent researches have demonstrated that PEDF has an anti-tumor effect against several human neoplasms. This review focuses on the pathological role of PEDF in tumors, especially tumor growth and metastasis. PEDF is an endogenous anti-tumor factor and its clinical application seems quite promising, although there is much to be further investigated.
MeSH terms
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Angiogenesis Inhibitors / metabolism*
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Angiogenesis Inhibitors / therapeutic use
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Apoptosis / physiology
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Endothelium, Vascular / metabolism
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Endothelium, Vascular / pathology
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Endothelium, Vascular / physiology
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Eye Proteins / metabolism*
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Eye Proteins / therapeutic use
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Humans
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Neoplasm Metastasis* / drug therapy
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Neoplasms* / drug therapy
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Neoplasms* / metabolism
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Neoplasms* / pathology
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Neovascularization, Pathologic* / drug therapy
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Nerve Growth Factors / metabolism*
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Nerve Growth Factors / therapeutic use
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Protease Inhibitors / metabolism*
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Protease Inhibitors / therapeutic use
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Serpins / metabolism*
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Serpins / therapeutic use
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Signal Transduction / physiology
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fas Receptor / metabolism
Substances
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Angiogenesis Inhibitors
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Eye Proteins
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Nerve Growth Factors
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Protease Inhibitors
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Serpins
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fas Receptor
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pigment epithelium-derived factor