The role of PEDF in tumor growth and metastasis

Curr Mol Med. 2010 Apr;10(3):292-5. doi: 10.2174/156652410791065327.

Abstract

Pigment epithelium-derived factor (PEDF), one of the non-inhibitory serpines, is widely expressed throughout the body. Although PEDF was initially identified as a neuronal differentiation factor, more attention has been paid to its anti-angiogenic activity. Additionally, recent researches have demonstrated that PEDF has an anti-tumor effect against several human neoplasms. This review focuses on the pathological role of PEDF in tumors, especially tumor growth and metastasis. PEDF is an endogenous anti-tumor factor and its clinical application seems quite promising, although there is much to be further investigated.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inhibitors / metabolism*
  • Angiogenesis Inhibitors / therapeutic use
  • Apoptosis / physiology
  • Endothelium, Vascular / metabolism
  • Endothelium, Vascular / pathology
  • Endothelium, Vascular / physiology
  • Eye Proteins / metabolism*
  • Eye Proteins / therapeutic use
  • Humans
  • Neoplasm Metastasis* / drug therapy
  • Neoplasms* / drug therapy
  • Neoplasms* / metabolism
  • Neoplasms* / pathology
  • Neovascularization, Pathologic* / drug therapy
  • Nerve Growth Factors / metabolism*
  • Nerve Growth Factors / therapeutic use
  • Protease Inhibitors / metabolism*
  • Protease Inhibitors / therapeutic use
  • Serpins / metabolism*
  • Serpins / therapeutic use
  • Signal Transduction / physiology
  • fas Receptor / metabolism

Substances

  • Angiogenesis Inhibitors
  • Eye Proteins
  • Nerve Growth Factors
  • Protease Inhibitors
  • Serpins
  • fas Receptor
  • pigment epithelium-derived factor