MLL insertion with MLL-MLLT3 gene fusion in acute leukemia: case report and review of the literature

Gwendoline Soler; Isabelle Radford; Claus Meyer; Rolf Marschalek; Chantal Brouzes; David Ghez; Serge Romana; Roland Berger

doi:10.1016/j.cancergencyto.2008.01.016

MLL insertion with MLL-MLLT3 gene fusion in acute leukemia: case report and review of the literature

Cancer Genet Cytogenet. 2008 May;183(1):53-9. doi: 10.1016/j.cancergencyto.2008.01.016.

Authors

Gwendoline Soler¹, Isabelle Radford, Claus Meyer, Rolf Marschalek, Chantal Brouzes, David Ghez, Serge Romana, Roland Berger

Affiliation

¹ Service de cytogénétique, Assistance PubliqueeHôpitaux de Paris, Centre Hospitalier Universitaire Necker-Enfants Malades, 149 rue de Sèvres, 75743, paris Cedex 15, France.

PMID: 18474298
DOI: 10.1016/j.cancergencyto.2008.01.016

Abstract

A new chromosomal insertion involving the MLL gene was detected by fluorescence in situ hybridization in a patient with acute myeloblastic leukemia (AML) and a t(9;11)(p21;q13). Genomic polymerase chain reaction confirmed the MLL-MLLT3 gene fusion. A review of the literature on MLL insertions shows that the opposite orientation of the genes involved in the fusion plays a role in the genesis of the rearrangement in most of the cases reported.

Publication types

Case Reports
Review

MeSH terms

Adult
Amino Acid Sequence
Base Sequence
Chromosome Breakage
Cytogenetic Analysis
Female
Histone-Lysine N-Methyltransferase
Humans
Leukemia, Myeloid, Acute / genetics*
Molecular Sequence Data
Mutagenesis, Insertional*
Myeloid-Lymphoid Leukemia Protein / genetics*
Nuclear Proteins / genetics*
Oncogene Proteins, Fusion / genetics*

Substances

KMT2A protein, human
MLL-MLLT3 fusion protein, human
MLLT3 protein, human
Nuclear Proteins
Oncogene Proteins, Fusion
Myeloid-Lymphoid Leukemia Protein
Histone-Lysine N-Methyltransferase