Abstract
Numerous components and pathways are involved in the complex interplay between cancer cells and their environment. The family of glycophosphoproteins comprising osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein - small integrin-binding ligand N-linked glycoproteins (SIBLINGs) - are emerging as important players in many stages of cancer progression. From their detection in various human cancers to the demonstration of their key functional roles during malignant transformation, invasion and metastasis, the SIBLINGs are proteins with potential as diagnostic and prognostic tools, as well as new therapeutic targets.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Disease Progression
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Extracellular Matrix Proteins / genetics*
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Extracellular Matrix Proteins / metabolism
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Gene Expression Regulation, Neoplastic*
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Glycoproteins / genetics*
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Glycoproteins / metabolism
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Humans
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Integrins / metabolism
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Ligands
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Models, Biological
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Neoplasm Metastasis
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Neoplasms / genetics*
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Neoplasms / metabolism*
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Neoplasms / pathology*
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Neovascularization, Pathologic
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Osteopontin / biosynthesis
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Phosphoproteins / genetics*
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Phosphoproteins / metabolism
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Prognosis
Substances
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Extracellular Matrix Proteins
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Glycoproteins
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Integrins
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Ligands
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Phosphoproteins
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Osteopontin