Abstract
Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional regulators, which control a wide spectrum of biological processes. As a consequence, a loss or gain of Fox function can alter cell fate and promote tumorigenesis as well as cancer progression. Here we discuss the evidence that the deregulation of Fox family transcription factors has a crucial role in the development and progression of cancer, and evaluate the emerging role of Fox proteins as direct and indirect targets for therapeutic intervention, as well as biomarkers for predicting and monitoring treatment responses.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use
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Cell Transformation, Neoplastic / genetics
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Disease Progression
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Drug Design
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Female
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Forkhead Transcription Factors / antagonists & inhibitors
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Forkhead Transcription Factors / chemistry
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Forkhead Transcription Factors / genetics
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Forkhead Transcription Factors / physiology*
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Gene Expression Regulation, Developmental / genetics
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Gene Expression Regulation, Developmental / physiology
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Gene Expression Regulation, Neoplastic / genetics
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Gene Expression Regulation, Neoplastic / physiology*
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Homeostasis
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Humans
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Immunity / genetics
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Male
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Mice
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Mice, Knockout
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Multigene Family
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Neoplasm Proteins / antagonists & inhibitors
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Neoplasm Proteins / chemistry
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Neoplasm Proteins / genetics
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Neoplasm Proteins / physiology*
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Neoplasms / drug therapy
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Neoplasms / genetics
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Neoplasms / metabolism
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Neoplasms / physiopathology*
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Phylogeny
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Protein Processing, Post-Translational
Substances
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Antineoplastic Agents
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Forkhead Transcription Factors
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Neoplasm Proteins