Abstract
The survival and growth of tumor cells within the microenvironment of a solid tumor necessitates the adaptation of these cells to ER stress. Hypoxia, in the context of the tumor microenvironment, is a critical ER stress that activates the unfolded protein response (UPR). This review focuses on the role of the IRE1-XBP1 branch of the UPR and its role in mediating cell survival and tumor growth. Inhibition of this pathway will be discussed as a therapeutic strategy.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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DNA-Binding Proteins / antagonists & inhibitors*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Endoplasmic Reticulum / metabolism
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Humans
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Hypoxia / genetics
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Hypoxia / metabolism*
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Iron Regulatory Protein 1 / metabolism
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Neoplasms / genetics
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Neoplasms / metabolism*
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Neoplasms / therapy*
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Protein Folding
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Regulatory Factor X Transcription Factors
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Transcription Factors / antagonists & inhibitors*
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Transcription Factors / genetics
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Transcription Factors / metabolism*
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Up-Regulation
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X-Box Binding Protein 1
Substances
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DNA-Binding Proteins
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Regulatory Factor X Transcription Factors
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Transcription Factors
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X-Box Binding Protein 1
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XBP1 protein, human
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Iron Regulatory Protein 1