Abstract
Systemic lupus erythematosus is an autoimmune disease that causes inflammation in the tissues of the brain, endothelial cells, gastrointestinal/genitourinary (GI/GU), joints, kidneys, muscles, and skin. Lupus comprises a range of multisystem disorders involving the deposition of aberrant immune complexes into tissues. Inflammation occurs as a result of autoantibodies attacking organ systems. The pathogenesis of systemic lupus erythematosus is presented.
MeSH terms
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Antigen-Antibody Complex / immunology
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Antigen-Presenting Cells / immunology
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Autoantibodies / immunology
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B-Lymphocytes / immunology
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Cytokines / immunology
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Genes, MHC Class II / immunology
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Humans
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Immune Tolerance / immunology
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Immunity, Cellular / immunology
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Inflammation
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Lupus Erythematosus, Systemic / complications
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Lupus Erythematosus, Systemic / epidemiology
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Lupus Erythematosus, Systemic / immunology*
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Lymphatic System / immunology
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Lymphocytes / immunology
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Macrophages / immunology
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Self Tolerance / immunology
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T-Lymphocytes / immunology
Substances
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Antigen-Antibody Complex
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Autoantibodies
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Cytokines