Abstract
In vitro and in vivo experiments showed that anticoagulant activity of sulfated polysaccharide from Fucus evanescens (brown algae of the Okhotsk Sea) was similar to that of heparin. Anticoagulant properties of fucoidan are determined by thrombin inhibition mediated via plasma antithrombin III.
MeSH terms
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Animals
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Anticoagulants / chemistry
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Anticoagulants / pharmacology*
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Blood Coagulation Tests
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Dose-Response Relationship, Drug
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Fucus / chemistry*
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Heparin / pharmacology
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Humans
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Mice
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Mice, Inbred BALB C
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Oceans and Seas
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Polysaccharides / chemistry
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Polysaccharides / pharmacology*
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Russia
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Time Factors
Substances
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Anticoagulants
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Polysaccharides
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Heparin
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fucoidan