Abstract
ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis
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Gene Expression Regulation*
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Humans
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Insulin / metabolism
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Intracellular Signaling Peptides and Proteins
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Models, Biological
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Muscle, Smooth / metabolism
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Phagocytosis
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Phosphorylation
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Phylogeny
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Protein Isoforms
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Protein Serine-Threonine Kinases / metabolism
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Protein Serine-Threonine Kinases / physiology*
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Signal Transduction
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rho-Associated Kinases
Substances
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Insulin
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Intracellular Signaling Peptides and Proteins
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Protein Isoforms
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Protein Serine-Threonine Kinases
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rho-Associated Kinases