Abstract
A recent paper in Cell (Fujita et al., 2003) demonstrates that MTA3, a novel component of the Mi-2/NuRD transcriptional repression complex, is an estrogen receptor-regulated inhibitor of the Snail zinc finger transcription factor in breast cancer. Given the important role of Snail in repressing E-cadherin transcription and the function of E-cadherin as a tumor suppressor protein and regulator of epithelial architecture, the findings offer potentially significant new insights into cancer pathogenesis.
MeSH terms
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Breast Neoplasms / genetics*
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Breast Neoplasms / metabolism
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Cadherins / biosynthesis*
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DNA-Binding Proteins / genetics
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Female
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Gene Expression Profiling
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Gene Silencing
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Humans
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Mutation
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Neoplasm Proteins / genetics
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Receptors, Estrogen / physiology*
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Signal Transduction
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Snail Family Transcription Factors
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Transcription Factors / genetics
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Transcription, Genetic
Substances
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Cadherins
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DNA-Binding Proteins
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MTA3 protein, human
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Neoplasm Proteins
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Receptors, Estrogen
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Snail Family Transcription Factors
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Transcription Factors