Abstract
TOR--a highly conserved atypical protein kinase and the 'target of rapamycin', an immunosuppressant and anti-cancer drug--controls cell growth. TOR controls the growth of proliferating yeast, fly and mammalian cells in response to nutrients. Recent findings, however, indicate that TOR also controls the growth of non-proliferating cells, such as neurons and muscle cells. Furthermore, TOR, by associating with regulatory proteins and inhibiting phosphatases, controls the activity of multiphosphorylated effectors.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Drosophila Proteins / physiology*
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Drosophila melanogaster
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Humans
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Phosphatidylinositol 3-Kinases / physiology*
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Phosphotransferases (Alcohol Group Acceptor) / physiology*
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Receptor Protein-Tyrosine Kinases / physiology*
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Saccharomyces cerevisiae Proteins / physiology*
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Signal Transduction*
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Tacrolimus Binding Protein 1A / physiology*
Substances
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Drosophila Proteins
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Saccharomyces cerevisiae Proteins
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Phosphatidylinositol 3-Kinases
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Phosphotransferases (Alcohol Group Acceptor)
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TOR1 protein, S cerevisiae
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Receptor Protein-Tyrosine Kinases
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tor protein, Drosophila
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Tacrolimus Binding Protein 1A