Abstract
Gab proteins, including mammalian Gab1, Gab2, Gab3, Drosophila DOS and Caenorhabditis elegans Soc1, comprise a growing family of scaffolding/docking molecules involved in multiple signaling pathways mediated by receptor tyrosine kinases (RTKs) and non-RTK receptors. This paper reviews the structure/function relationships of Gab proteins and their biological roles during normal growth, differentiation and development programs.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing
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Animals
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Caenorhabditis elegans Proteins / physiology
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Carrier Proteins / physiology*
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Drosophila Proteins*
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Eye Proteins / physiology
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Gene Expression
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Humans
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Phosphoproteins / physiology*
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Phosphorylation
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Signal Transduction / physiology
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Tyrosine / metabolism
Substances
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Adaptor Proteins, Signal Transducing
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Caenorhabditis elegans Proteins
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Carrier Proteins
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Dos protein, Drosophila
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Drosophila Proteins
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Eye Proteins
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GAB1 protein, human
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GAB2 protein, human
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Gab1 protein, mouse
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Gab2 protein, mouse
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Gab3 protein, mouse
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Phosphoproteins
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soc-1 protein, C elegans
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Tyrosine