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TGF-β and epithelial-to-mesenchymal transitions

Abstract

Remarkable phenotype plasticity of epithelial cells underlies morphogenesis, epithelial repair and tumor invasiveness. Detailed understanding of the contextual cues and molecular mediators that control epithelial plasticity will be required in order to develop viable therapeutic approaches targeting epithelial-to-mesenchymal transition (EMT), an advanced manifestation of epithelial plasticity. Members of the transforming growth factor (TGF-β) family of growth factors can initiate and maintain EMT in a variety of biological systems and pathophysiological context by activating major signaling pathways and transcriptional regulators integrated in extensive signaling networks. Here we will review the distinct physiological contexts of EMT and the underlying molecular signaling networks controlled by TGF-β.

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Acknowledgements

We thank Anita Roberts for her tireless, outstanding mentoring. This work was supported by the following Grants: National Institutes of Health R01 DK060043, R01 DK056077, and P50 DK064236-010003 to EPB.

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Zavadil, J., Böttinger, E. TGF-β and epithelial-to-mesenchymal transitions. Oncogene 24, 5764–5774 (2005). https://doi.org/10.1038/sj.onc.1208927

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