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The protein tyrosine kinase family of the human genome

Oncogene volume 19, pages 5548–5557 (2000)Cite this article

Abstract

As the sequencing of the human genome is completed by the Human Genome Project, the analysis of this rich source of information will illuminate many areas in medicine and biology. The protein tyrosine kinases are a large multigene family with particular relevance to many human diseases, including cancer. A search of the human genome for tyrosine kinase coding elements identified several novel genes and enabled the creation of a nonredundant catalog of tyrosine kinase genes. Ninety unique kinase genes can be identified in the human genome, along with five pseudogenes. Of the 90 tyrosine kinases, 58 are receptor type, distributed into 20 subfamilies. The 32 nonreceptor tyrosine kinases can be placed in 10 subfamilies. Additionally, mouse orthologs can be identified for nearly all the human tyrosine kinases. The completion of the human tyrosine kinase family tree provides a framework for further advances in biomedical science.

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Acknowledgements

We would like to thank Dr H-J Kung for valuable discussions and support. We acknowledge all those whose relevant contributions we were unable to cite in this review due to space limitations. This work was supported by NIH grant ROI CA82073.

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  1. Department of Biological Chemistry, UC Davis School of Medicine, UC Davis Cancer Center, Sacramento, 95817, California, CA, USA

    Dan R Robinson, Yi-Mi Wu & Su-Fang Lin

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Robinson, D., Wu, YM. & Lin, SF. The protein tyrosine kinase family of the human genome. Oncogene 19, 5548–5557 (2000). https://doi.org/10.1038/sj.onc.1203957

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