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A new structural analysis of DNA using statistical models of infrared spectra

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References

  1. Steenken, S. Purine bases, nucleosides, and nucleotides: Aqueous solution redox chemistry and transformation reactions of their radical cations and e and OH adducts. Chem. Rev. 89, 503–520 (1989).

    Article  CAS  Google Scholar 

  2. Malins, D.C., Polissar, N.L. & Gunselman, S.J. Tumor progression to the metastatic state involves structural modifications in DNA markedly different from those associated with primary tumor formation. Proc. Natl. Acad. Sci. USA 93, 14047–14052 (1996).

    Article  CAS  Google Scholar 

  3. Monforte, J.A. & Becker, C.H. High-throughput DNA analysis by time-of-flight mass spectrometry. Nature Med. 3, 360–362 (1997).

    Article  CAS  Google Scholar 

  4. Malins, D.C., Polissar, N.L. & Gunselman, S.J. Models of DNA structure achieve almost perfect discrimination between normal prostate, benign prostatic hyperplasia (BPH), and adenocarcinoma and have a high potential for predicting BPH and prostate cancer. Proc. Natl. Acad. Sci. USA 94, 259–264 (1997).

    Article  CAS  Google Scholar 

  5. Malins, D.C., Polissar, N.L. & Gunselman, S.J. Progression of human breast cancers to the metastatic state is linked to hydroxyl radical-induced DNA damage. Proc. Natl. Acad. Sci. USA 93, 2557–2563 (1996).

    Article  CAS  Google Scholar 

  6. Malins, D.C. et al. The etiology and prediction of breast cancer: Fourier transform-infrared spectroscopy reveals progressive alterations in breast DNA leading to a cancer-like phenotype in a high proportion of normal women. Cancer 75, 503–517 (1995).

    Article  CAS  Google Scholar 

  7. Kirby, R.S., Christmas, T.J. & Brawer, M. Prostate Cancer (Mosby, Alfred Place, London, 1996).

    Google Scholar 

  8. Camplejohn, R.S. DNA damage and repair in melanoma and non-melanoma skin cancer. Cancer Surv. 26, 193–206 (1996).

    CAS  PubMed  Google Scholar 

  9. Okamoto, A., Okabe, M. & Gomi, K. Analysis of DNA fragmentation in human uterine cervix carcinoma HeLa S3 cells treated with duocarmycins or other antitumor agents by pulse-field gel electrophoresis. Jpn. J. Cancer Res. 84, 93–98 (1993).

    Article  CAS  Google Scholar 

  10. Mecocci, P., MacGarvey, U. & Beal, M.F. Oxidative damage to mitochondrial DMA is increased in Alzheimer's disease. Ann. Neurol. 36, 747–751 (1994).

    Article  CAS  Google Scholar 

  11. Dandona, P. et al. Oxidative damage to DMA in diabetes mellitus. Lancet 347, 444–445 (1996).

    Article  CAS  Google Scholar 

  12. Ferrari, R. The role of mitochondria in ischemic heart disease. J. Cardiovasc. Pharmacol. 28, Suppl. 1, S1–S10 (1996).

    CAS  PubMed  Google Scholar 

  13. Jenner, P. Oxidative stress in Parkinson's disease and other neurodegenerative disorders. Pathol. Biol. (Paris) 44, 57–64 (1996).

    CAS  Google Scholar 

  14. Dees, C., Garrett, S., Henley, D. & Travis, C. Effects of 60-Hz fields, estradiol and xenoestrogens on human breast cancer cells. Radiat. Res. 146, 444–452 (1996).

    Article  CAS  Google Scholar 

  15. Sikka, S.C., Rajasekaran, M. & Hellstrom, W.J. Role of oxidative stress and antioxidants in male infertility. J. Androl. 16, 464–481 (1995).

    CAS  PubMed  Google Scholar 

  16. Algan, O., Stobbe, C.C., Helt, A.M., Hanks, G.E. & Chapman, J.D. Radiation inactivation of human prostate cancer cells: The role of apoptosis. Radiat. Res. 146, 267–275 (1996).

    Article  CAS  Google Scholar 

  17. Mandavilli, B.S. & Rao, K.S. Accumulation of DMA damage in aging neurons occurs through a mechanism other than apoptosis. J. Neurochem. 67, 1559–1565 (1996).

    Article  CAS  Google Scholar 

  18. Wender, P.A., Kelly, R.C., Beckham, S. & Miller, B.L. Studies on DNA-cleaving agents: Computer modeling analysis of the mechanism of activation and cleavage of dynemicin–oligonucleotide complexes. Proc. Natl. Acad. Sci. USA 88, 8835–8839 (1991).

    Article  CAS  Google Scholar 

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Malins, D., Polissar, N., Su, Y. et al. A new structural analysis of DNA using statistical models of infrared spectra. Nat Med 3, 927–930 (1997). https://doi.org/10.1038/nm0897-927

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