Abstract
The pathogenesis of metastasis begins with the invasion of tissues, blood vessels and/or lymphatics by cells originating from a primary cancer. Following their release into the circulation, most tumour emboli are initially arrested in the first capillary bed encountered, but some recirculate and are trapped in other organs. After their initial arrest, tumour cells must invade the parenchyma, establish a micro-environment, escape host defence mechanisms and finally grow into secondary tumours1.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Hepatic passaging of NRAS-mutant melanoma influences adhesive properties and metastatic pattern
BMC Cancer Open Access 13 May 2023
-
IFNγ binding to extracellular matrix prevents fatal systemic toxicity
Nature Immunology Open Access 02 February 2023
-
Current methods for studying metastatic potential of tumor cells
Cancer Cell International Open Access 09 December 2022
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Zeidman, I., Cancer Res., 17, 157 (1957).
Fidler, I. J., J. Nat. Cancer Inst., 45, 773 (1970).
Fidler, I. J., and Zeidman, I., J. Med., 3, 172 (1972).
Zeidman, I., McCutcheon, M., and Coman, D. R., Cancer Res., 10, 357 (1950).
Klein, G., Proc. Third Canadian Cancer Conf., 215 (Academic Press, New York, 1959).
Fisher, B., and Fisher, E. R., Cancer Res., 27, 412 (1967).
Zeidman, I., and Buss, M., Cancer Res., 12, 371 (1952).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FIDLER, I. Selection of Successive Tumour Lines for Metastasis. Nature New Biology 242, 148–149 (1973). https://doi.org/10.1038/newbio242148a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/newbio242148a0
This article is cited by
-
Hepatic passaging of NRAS-mutant melanoma influences adhesive properties and metastatic pattern
BMC Cancer (2023)
-
IFNγ binding to extracellular matrix prevents fatal systemic toxicity
Nature Immunology (2023)
-
Connexin 45 is a novel suppressor of melanoma metastasis
Cytotechnology (2023)
-
Current methods for studying metastatic potential of tumor cells
Cancer Cell International (2022)
-
Polybrominated diphenyl ethers BDE-47 and BDE-99 modulate murine melanoma cell phenotype in vitro
Environmental Science and Pollution Research (2022)