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Acute Leukemias

Allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia with t(6;9)(p23;q34) dramatically improves the patient prognosis: a matched-pair analysis

Abstract

Acute myeloid leukemia (AML) with t(6;9)(p23;q34) is well known to have a poor prognosis treated with chemotherapy and autotransplantation. The presence of this karyotype is an indicator for allogeneic hematopoietic stem cell transplantation (HSCT); however, the impact of t(6;9)(p23;q34) on the HSCT outcome remains unclear. We conducted a matched-pair analysis of de novo AML patients with and without t(6;9)(p23;q34) using data obtained from the Japanese HSCT data registry. A total of 57 patients with t(6;9)(p23;q34) received transplants between 1996 and 2007, and 171 of 2056 normal karyotype patients matched for age, disease status at HSCT and graft source were selected. The overall survival, disease-free survival, cumulative incidence of relapse and the non-relapse mortality in t(6;9)(p23;q34) patients were comparable to those for normal karyotype patients. A univariate analysis showed that t(6;9)(p23;q34) had no significant impact on the overall survival. These findings suggest that allogeneic HSCT may overcome the unfavorable impact of t(6;9)(p23;q34) as an independent prognostic factor.

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Acknowledgements

We are indebted to all the patients and the staff of the participating institutions of the Japan Society for Hematopoietic Cell Transplantation, the Japan Marrow Donor Program, The Japanese Cord Blood Bank Network and The Japanese Society of Pediatric Hematology. We would like to thank Takako Sakai, data manager of the Japan Society for Hematopoietic Cell Transplantation Data Registry, for her excellent assistance.

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Correspondence to K Ishiyama.

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Ishiyama, K., Takami, A., Kanda, Y. et al. Allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia with t(6;9)(p23;q34) dramatically improves the patient prognosis: a matched-pair analysis. Leukemia 26, 461–464 (2012). https://doi.org/10.1038/leu.2011.229

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