Elsevier

Kidney International

Volume 78, Issue 3, 1 August 2010, Pages 231-234
Kidney International

Commentary
JAK/STAT signaling in renal diseases

https://doi.org/10.1038/ki.2010.158Get rights and content
Under an Elsevier user license
open archive

The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is a pleiotropic cascade essential to cytokine and growth hormone receptor signaling. Signaling through the JAK/STAT pathway is important for the kidney's response to injury in disease. Pang et al. confirm that activation of STAT3 mediates renal fibrosis in the unilateral ureteral obstruction experimental model.

Cited by (0)

The authors declared no competing interests.