Elsevier

Genomics

Volume 112, Issue 6, November 2020, Pages 4100-4114
Genomics

Mining therapeutic and prognostic significance of STATs in renal cell carcinoma with bioinformatics analysis

https://doi.org/10.1016/j.ygeno.2020.06.032Get rights and content
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Highlights

  • STAT1/2/4/6 were upregulated in RCC while STAT3/5B were downregulated

  • RCC patients with high expression of STAT2/4 and low/medium expression of STAT5B had a poor overall survival.

  • The function of STATs and the neighboring genes mainly enriched in JAK-STAT - and NOD-like receptor signaling pathway.

  • Close correlations were obtained between immune cell infiltration and STATs in RCC.

Abstract

Renal cell carcinoma is one of the most common malignancies with high morbidity and mortality. STAT proteins play a significant role in cell biological behavior and immune response associated with cancer progression. In our study, the datasets analyzed for the expression and potential functions can be found in several bioinformatics analysis tools. We found that STAT1/2/4/6 were upregulated in RCC while STAT3/5B were downregulated. The expression of STAT2/4/5B were significantly associated with the pathological stage of RCC patients. RCC patients with high expression of STAT2/4 and low/medium expression of STAT5B had a poor overall survival. The function of STATs and the neighboring genes mainly enriched in JAK-STAT signaling pathway and NOD-like receptor signaling pathway. Several transcription factor, kinase, and miRNA targets were identified. Close correlations were obtained between immune cell infiltration and STATs in RCC. Our results have provided novel insights for the selection of immunotherapeutic targets and prognostic biomarkers.

Keywords

Renal cell carcinoma
Biomarker
Bioinformatics analysis
STATs

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These authors contributed equally to this work.