Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress
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Abbreviations
APX
Ascorbate peroxidase
ATF4
Activating Transcription Factor 4
ATF6α
activating transcription factor 6α
ASK1
apoptosis signal-regulating kinase 1
CHOP
CAAT/enhancer binding protein (C/EBP) homologous protein
CRAC
Ca2+ release-activated Ca2+
ER
endoplasmic reticulum
eIF2α
eukaryotic translation initiation factor 2α
ERAD
ER-associated degradation
ERO1
ER oxidoreductin-1
GADD34
DNA damage gene 34
GPx7/8
glutathione peroxidase 7/8
GSH
reduced glutathione
GSSG
oxidized glutathione
GSTP
Glutathione S-Transferase P
IP3
inositol-1,4,5-trisphosphate
IP3R
inositol-1,4,5-trisphosphate receptor
IRE1α
inositol-requiring protein 1α
JNK
c-Jun NH2-terminal kinase
MAM
mitochondrial-associated membranes
NOX
NADPH oxidase
NRF2
nuclear factor erythroid 2-related factor 2
OPF
Oxidative protein folding
p-AKT
phosphorylated protein kinase B
PDI
protein disulfide isomerase
p-ERK
phosphorylated extracellular signal-regulated kinase
PERK
protein kinase RNA-like ER kinase
PRDX4
peroxiredoxin 4
QSOX
quiescin sulfhydryl oxidase
RIDD
regulated IRE1-dependent decay
ROS
reactive oxygen species
S1P
site-1 protease
S2P
site-2 protease
SERCA
sarcoplasmic/endoplasmic reticulum Ca2+-ATPases
SOCs
store operated Ca2+ channels
STIM1
stromal interaction molecule 1
TRAF2
TNF receptor-associated factor 2
TXNIP
thioredoxin interacting protein
UPR
unfolded protein response
VKOR
Vitamin K epoxide reductase
Vps34
vacuolar protein sorting 34
XBP1
X-box binding protein 1
Keywords
Redox regulation
ER stress
UPR
Cell fate
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These authors contribute equally to this work.
© 2018 The Authors. Published by Elsevier B.V.