Mini ReviewInterplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy
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Graphical abstract
Abbreviations
3-MA
3-methyladenine
AMPK
AMP-activated protein kinase
ATG
autophagy related gene
ATG8
autophagy related gene 8
BNIP3
BCL-2/adenovirus E1B 19-kDa-interacting protein 3
EMT
epithelial-mesenchymal transition
GABARAP
GABAA receptor-associated protein
GABARAPL1
GABARAP protein-like 1
GEC1
glandular epithelial cell 1
GABARAPL2
GABARAP protein-like 2
HIF-1α
hypoxia-inducible factor-1 α
HMGB1
high-mobility group protein B 1
HSP
heat shock protein
KEAP1
Kelch-like ECH-associated protein 1
LC3
light chain 3
mTORC1
mammalian target of rapamycin complex
NLRP3
NOD-like receptor family, pyrin domain containing 3
NRF2
nuclear factor erythroid 2-related factor 2
PINK1
PTEN induced putative kinase 1
ROS
reactive oxygen species
SQSTM1
sequestosome 1
ULK1
unc-51 like autophagy activating kinase 1
Keywords
ROS
Mitochondria
Antioxidant
Mitophagy
Autophagy
Cancer
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Copyright © 2014 The Authors. Published by Elsevier B.V.