Malignant gliomaCharacterization and outcomes of infratentorial malignant glioma: A population-based study using the Surveillance Epidemiology and End-Results database
Section snippets
Materials and methods
We obtained data for this study through the National Cancer Institute sponsored Surveillance Epidemiology and End-Results (SEER) database, SEER-17 registry, released in November 2007 [12]. The SEER program is a population-based registry capturing de-identified personal data regarding individual cancer diagnoses and outcomes within the registry population. The registry population, as of the SEER-17 release, included a wide range of ethnic and demographic groups across the United States,
Results
A total of 455 patients were identified. The patients ranged in age from 0 to 87 years with a median age of 13 years. The majority of patients, 55.6%, were pediatric age (0–18 years). No significant gender predominance was noted in the cohort. The most common site of disease was confined to brainstem.
As indicated above, all patients identified for this study underwent surgery and/or radiation therapy. Radiation therapy was the most frequently employed treatment modality: 435 of 455 patients
Discussion
Infratentorial malignant glioma is a predominantly pediatric disease with a poor prognosis overall. The historical presentation and prognosis of pediatric brainstem glioma is reflected in our study. This study, however, also offers insight into the presentation of these tumors in adults and, to our knowledge, represents the largest series of adults with infratentorial malignant glioma. Unlike pediatric patients, younger adults tend to have better prognosis associated with lower grade tumors.
Conflict of interest statement
The authors have no relevant or potential conflicts of interest to disclose.
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