ReviewNuclear hormone receptor co-repressors: Structure and function
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Highlights
► Co-repressors SMRT/NCoR act as “hub proteins”. ► SMRT/NCoR integrate transcription factor and histone modifying enzyme signaling. ► Structures of co-repressor complexes. ► Structural studies provide mechanistic, and potentially therapeutic, insights.
Abbreviations
HDAC
histone deacetylase
HID
histone interaction domain
LBD
ligand binding domain
ID
interaction domain
RRM
RNA recognition motif
Keywords
Nuclear receptor
Co-repressor
SMRT/NCoR
TBL1
GPS2
HDAC
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