Elsevier

Journal of Controlled Release

Volume 313, 10 November 2019, Pages 80-95
Journal of Controlled Release

Review article
MicroRNA delivery through nanoparticles

https://doi.org/10.1016/j.jconrel.2019.10.007Get rights and content
Under a Creative Commons license
open access

Abstract

MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to their central role in the etiology of major diseases. On the other hand, nanoparticle carriers offer unprecedented opportunities for cell specific controlled delivery of miRNAs for therapeutic purposes. This review critically discusses the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of cancer and neurodegenerative disorders and for tissue regeneration. A fresh perspective is presented on the design and characterization of nanocarriers to accelerate translation from basic research to clinical application of miRNA-nanoparticles. Main challenges in the engineering of miRNA-loaded nanoparticles are discussed, and key application examples are highlighted to underline their therapeutic potential for effective and personalized medicine.

Keywords

Nanoparticles
Physicochemical characterization
Biomaterials
MicroRNA delivery and release
Personalized medicine

Cited by (0)

1

These authors equally contributed as first authors.

2

These authors equally contributed as last authors.

3

Present addresses.