Original contributionCutaneous myoepithelioma: a clinicopathologic and immunohistochemical study of 14 cases
Section snippets
Materials and methods
We retrieved the cases used in this study from the consultation files of one of the authors (C.D.M.F.); see the Acknowledgment. Two cases (cases 5 and 9) were subsequently published by the original referring pathologists;11 we obtained additional clinical follow-up for both of these cases. For the diagnosis of cutaneous myoepithelioma, we applied similar criteria to those established for comparable salivary gland lesions12, 13, 14 and, more recently, soft tissue tumors.15 The tumors are solid
Clinical findings
The clinical features are summarized in Table 2. The study group comprised 11 males and 3 females. The age at diagnosis ranged from 10 to 63 years, with a median of 22.5 years; 7 patients were between 10 and 20 years old. The duration of symptoms before excision ranged from 1 month to 20 years. Seven cases presented as painless cutaneous nodules, of which 4 were slowly growing and 1 was associated with recently increasing pain. One tumor (case 2) grew rapidly and was described as a tender
Discussion
Mixed tumors of skin (“ chondroid syringomas”)1, 2, 3 are circumscribed nodular dermal lesions composed of an admixture of ductal structures and areas of myxoid or chondroid stroma containing ovoid, spindled, or plasmacytoid (hyaline) cells. Cutaneous mixed tumors are generally subclassified as apocrine or eccrine in type.1, 5 The epithelial component in apocrine mixed tumors comprises branching tubular structures composed of 2 cell layers, the inner layer generally columnar with basally
Addendum
Since the date that this manuscript was submitted for publication, an additional series of 20 cutaneous myoepithelial neoplasms has been published (Mentzel T, et al: Cutaneous myoepithelial neoplasms: Clinicopathologic and immunohistochemical study of 20 cases. J Cutan Pathol 30: 294–302, 2003), including 9 mixed tumors (chondroid syringomas), 9 myoepitheliomas, and 2 myoepithelial carcinomas. The findings of that study are similar to those reported herein.
Acknowledgements
The authors thank the following pathologists who kindly provided case material and clinical follow-up when available: Dr. H. Sonobe, Kochi, Japan; Dr. D. Ranchere-Vince, Lyon, France; Drs. S. Kaddu and H. P. Soyer, Graz, Austria; Dr. H. Kutzner, Friedrichshafen, Germany; Dr. P. Chu, New Rochelle, NY; Dr. J. McNiff, New Haven, CT; and Dr. E. Heilman, Port Chester, NY.
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