Elsevier

EBioMedicine

Volume 21, July 2017, Pages 14-20
EBioMedicine

Review
Telomeres and Cell Senescence - Size Matters Not

https://doi.org/10.1016/j.ebiom.2017.03.027Get rights and content
Under a Creative Commons license
open access

Highlights

  • Telomere shortening occurs with cell division and limits replicative capacity of cells, also known as replicative senescence.

  • Senescent cells accumulate with age and in age-related diseases, and are associated with loss of tissue function with aging.

  • Telomere damage can occur independently of length, and this has been shown to contribute to the senescent phenotype.

Abstract

Telomeres are protective structures present at the ends of linear chromosomes that are important in preventing genome instability. Telomeres shorten as a result of cellular replication, leading to a permanent cell cycle arrest, also known as replicative senescence. Senescent cells have been shown to accumulate in mammalian tissue with age and in a number of age-related diseases, suggesting that they might contribute to the loss of tissue function observed with age. In this review, we will first describe evidence suggesting a key role for senescence in the ageing process and elaborate on some of the mechanisms by which telomeres can induce cellular senescence. Furthermore, we will present multiple lines of evidence suggesting that telomeres can act as sensors of both intrinsic and extrinsic stress as well as recent data indicating that telomere–induced senescence may occur irrespectively of the length of telomeres.

Keywords

Telomeres
Senescence
Stress
Ageing
DNA damage

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