Cell Metabolism
Volume 19, Issue 5, 6 May 2014, Pages 757-766
Journal home page for Cell Metabolism

Review
Mitohormesis

https://doi.org/10.1016/j.cmet.2014.01.011Get rights and content
Under an Elsevier user license
open archive

For many years, mitochondria were viewed as semiautonomous organelles, required only for cellular energetics. This view has been largely supplanted by the concept that mitochondria are fully integrated into the cell and that mitochondrial stresses rapidly activate cytosolic signaling pathways that ultimately alter nuclear gene expression. Remarkably, this coordinated response to mild mitochondrial stress appears to leave the cell less susceptible to subsequent perturbations. This response, termed mitohormesis, is being rapidly dissected in many model organisms. A fuller understanding of mitohormesis promises to provide insight into our susceptibility for disease and potentially provide a unifying hypothesis for why we age.

Cited by (0)