Cancer Cell
Volume 39, Issue 2, 8 February 2021, Pages 209-224.e11
ArticleMAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage
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Graphical Abstract
Keywords
MAT2A
PRMT5
splicing
detained introns
DNA damage
Fanconi anemia complex
R loops
taxanes
synergy
Cited by (0)
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Present address: Rheos Medicines, Cambridge, MA 02142, USA
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Present address: Exploratory Biology, Novartis Institutes for Biomedical Research, Cambridge, MA 02319, USA
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Present address: Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA 02319, USA
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Present address: Chemistry, Takeda Pharmaceutical Co., Ltd., Lexington, MA 02421, USA
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Present address: Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
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These authors contributed equally
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