Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1813, Issue 4, April 2011, Pages 558-563
ReviewCaspase-8 and Bid: Caught in the act between death receptors and mitochondria☆
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Research Highlights
► We describe the role of mitochondria in caspase-8 signalling. ► Polyubiquitination of caspase-8 at the DISC modulates its activation. ► The cardiolipin enriched “mitosome” is a new activation platform for caspase-8. ► MTCH2/MIMP facilitates the recruitment of active tBid to the mitochondria. ► The type I/type II cell discrimination is also due to differences on XIAP levels.
Keywords
Caspase-8
Mitochondria
Bid
Type II cells
Death inducing signalling complex
XIAP
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This article is part of a Special Issue entitled Mitochondria: the deadly organelle.
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