Evidence that “myofibroblast-like” cells are the cellular source of capsular collage in hepatocellular carcinoma
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2018, BiomaterialsCitation Excerpt :The tumor microenvironment, consisting of stromal cells, extracellular matrix (ECM) molecules and various soluble factors, is a critical determinant for cancer development by providing a structural scaffold for neoplastic and non-neoplastic cells, thus offers a myriad of alternative targets for therapeutic agent [1]. Collagen, as the most prevalent proteins in ECM, has been reported composing the encapsulation around tumor tissues, which is associated with a lower incidence of tumor invasion, microsatellites and venous permeation when compared with non-encapsulated tumors, and patients with encapsulated tumors have a better prognosis [2–4]. Fibroblasts, especially cancer-associated fibroblasts (CAFs), as a major cell type responsible for the production of collagen in tumor stroma, impact tumor growth and progression through collagen-mediated encapsulation of carcinogens [2–5].
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