REGULAR ARTICLEPAI-I 4G/5G polymorphism and sudden cardiac death in patients with coronary artery disease☆
Section snippets
Sudden Cardiac Death
SCD was defined as death occurring within 1 h of the development of symptoms in a patient previously in stable condition and with no evidence of myocardial damage during the preceding 24 h.
Study Population
A total of 210 Caucasian patients from the same region were selected. Ninety-seven patients with CAD were survivors of SCD with documented ventricular tachycardia and/or ventricular fibrillation not associated with acute myocardial infarction, who successfully underwent cardiopulmonary resuscitation. These
Results
The baseline characteristics of the study groups are summarized in Table 1. There were no significant differences between the two study groups.
Discussion
In survivors of SCD with underlying CAD, electrocardiographic changes or elevated enzyme levels suggestive of acute myocardial cell damage were found in up to 44% of the patients [3], [4]. For the remaining individuals, different mechanisms should be postulated: a transient ischemic episode too short to result in myocardial damage might be assumed.
A reduction of the endogenous fibrinolytic potential is commonly related to increased plasma levels of PAI-I [8], [9], which, in turn, have been
References (17)
- et al.
Long-term follow-up of survivors of prehospital sudden death treated with coronary bypass surgery
Am Heart J
(1985) - et al.
Effect of antithrombotic therapy on risk of sudden coronary death in patients with congestive heart failure
Am J Cardiol
(1997) - et al.
Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction
Lancet
(1987) - et al.
The 4G/5G polymorphism of the plasminogen activator inhibitor gene is associated with the time course of the progression to acute coronary syndromes
Atherosclerosis
(1998) - et al.
Risk factor profiles of patients with sudden cardiac death and death from other cardiac causes: a report from the coronary artery surgery study (CASS)
J Am Coll Cardiol
(1989) - et al.
The epidemiology of sudden unexpected death: risk factors for men and women in the Framingham Heart Study
Am Heart J
(1984) - et al.
Sudden cardiac death: 1. A decade's experience with out of hospital resuscitation
Mod Concepts Cardiovasc Dis
(1980) - et al.
Characteristics of the resuscitated sudden death victims with coronary heart disease
Circulation
(1981)
Cited by (36)
Impact of PAI-1 4G/5G and C > G polymorphisms in acute ST elevation myocardial infarction and stable angina patients: A single center Egyptian study
2018, Egyptian Journal of Medical Human GeneticsCitation Excerpt :Among these polymorphisms: 4G/5G insertion/deletion polymorphism at −675 bp of the gene promoter, in addition to C > G polymorphism at the 3′untranslated region (UTR) [16]. PAI-1 4G/5G gene polymorphism and the risk of CAD was thoroughly studied with conflicting data; some studies approving its role in the increased risk of CAD [17,18] while others did not [19,20]. This preliminary study aimed at evaluating the possible role of PAI-1 4G/5G and PAI-1C > G polymorphisms in Egyptian patients with CAD compared to a group of non-ischemic patients.
Genetics of Sudden Cardiac Arrest
2008, Progress in Cardiovascular DiseasesCitation Excerpt :The 4G/5G polymorphism in the plasminogen activator inhibitor 1 (PAI-1) gene leads to down-regulation of endogenous fibrinolysis through reduced circulating PAI-1 levels. In a subsequent study in the same population as the ACE/AT1 study, Anvari et al53 examined 97 survivors of SCA with underlying CAD and 113 controls with CAD and no ventricular arrhythmias for the 4G/5G variants. The investigators found an increased prevalence of the 4G/4G genotype in those with CAD who survived SCA vs those who had not had an arrhythmic event.
Is there a genetic basis for malignant ventricular arrhythmias?
2005, Heart RhythmSusceptibility genes and modifiers for cardiac arrhythmias
2005, Cardiovascular ResearchGenetic variations of renin-angiotensin and fibrinolytic systems and susceptibility to coronary artery disease: a population genetics perspective
2022, Minerva Cardiology and Angiology
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A part of these data was presented at the American College of Cardiology 48th and North American Society of Pacing and Electrophysiology 20th Annual Scientific Session 1999 in New Orleans and Toronto, respectively.