International Journal of Radiation Oncology*Biology*Physics
Original contributionQuality of long-term survival following irradiation for intracranial tumors in children under the age of two☆
References (63)
Treatment of Grades I and II brain astrocytomas-The role of radiotherapy
Int. J. Rad. Oncol. Biol. Phys.
(1977)- et al.
Complications of radiation therapy—The central nervous system
Sem. Roentgenol.
(1974) - et al.
Delayed onset of hypopituitarism: Sequelae of therapeutic irradiation of central nervous system, eye, and middle ear tumors
J. Pediat.
(1976) - et al.
Hypopituitarism after irradiation in children
Int. J. Rad. Oncol. Biol. Phys.
(1977) - et al.
Brain tumors in children-Analysis of 136 cases
Radiology
(1974) The Arthur Adaptation of the Leiter International Performance Scale
- et al.
Residual disabilities in children treated for intracranial space-occupying lesions
Cancer
(1976) - et al.
Children's Apperception Test
Visual Motor Gestalt Test
- et al.
The treatment and prognosis of medulloblastoma in children
Am. J. Roentgenol.
(1969)
Radiation therapy in the management of primary brain tumors
Ann. N.Y. Acad. Sci.
Radiation therapy in the management of neoplasms of the central nervous system, with a special note in regard to children: Twenty years' experience, 1939–1958
Am. J. Roentgenol.
An operative staging system and a megavoltage radiotherapeutic technique for cerebellar medulloblastoma
Radiology
Complications of treatment encountered in lymphoma-leukemia long-term survivors
Cancer
Peabody Picture Completion Test
Intracranial neoplasms in infants
Arch. Neurol.
Cerebral tumors in infancy
Am. J. Dis. Child.
Long-term effects of external radiation on the pituitary and thyroid glands
Cancer
Behavioral effects of ionizing radiations 1955–1961
Psychol. Bull.
Astrocytomas of the cerebellum in children-Long-term study
Arch. Neurol.
Malignancy grade and long-term survival in brain tumours of infancy and childhood
Acta Neurol. Scand.
Cystic cerebellar astrocytomas in childhood
Cancer
Children's Drawings as Measures of Intellectual Maturity: A Revision and Extension of the Goodenough Draw-a-Man Test
Hypothalamic-pituitary function following successful treatment of intracranial tumours
Clin. Endocrinol.
Calcification of the basal ganglia following radiation therapy
Am. J. Roentgenol.
Assessment of hypothalamic-pituitary function in women after external head irradiation
J. Clin. Endocrinol. Metab.
Wide Range Achievement Test
Clinical evaluation of anticancer drugs
Gann Monograph on Cancer Research
The hazards of therapeutic irradiation of the central nervous system
Clin. Neurosurg.
Radiation therapy in the management of brain tumors in children
Ann. N.Y. Acad. Sci.
Radiation therapy in the management of craniopharyngiomas
Cited by (114)
Brain Tumors and Vein of Galen Malformations
2018, Volpe's Neurology of the NewbornDevelopmental Aspects of Neuropsychology: Childhood
2013, NeuropsychologyRisk factors for cognitive decline in children treated for brain tumors
2010, European Journal of Paediatric NeurologyCitation Excerpt :One of the earliest studies evaluating quality of life was by Bloom et al. when they reported in 1969 that 82% of their patients treated for brain tumors had no long term disability related to surgery and radiation.1 Subsequently, however, retrospective reports began to surface in which children treated for brain tumors (primarily medulloblastoma) with surgery, radiation and in some cases adjuvant chemotherapy had significant intellectual disabilities, with the majority having IQs <70 and only 10–20% with IQs above 90.2–5 We, for example, reported a series of 10 children with posterior fossa tumors treated with surgery, radiation and a chemotherapy regimen which included methotrexate (MTX), BCNU, vincristine and dexamethasone.
High-grade glioma in children under 5 years of age: A chemotherapy only approach with the BBSFOP protocol
2006, European Journal of CancerRadiation as a nervous system toxin
2005, Neurologic ClinicsCitation Excerpt :Data in children treated for CNS tumors also indicate substantial evidence of IQ deterioration after radiotherapy [76,102–106]. These studies show that 17% to 31% of the children have IQs below 70 and that only 12% to 56% have IQs above 90 [104,107,108]. Lower IQs have been demonstrated in patients treated with radiation as opposed to chemotherapy or surgery for brain tumors [76,109], although cognitive impairment has been noted in patients treated with surgery alone [110].
Molecular Genetics and Targeted Therapies for Paediatric High-grade Glioma
2022, Cancer Genomics and Proteomics
- ☆
Presented at the Annual Meeting of the American Society of Therapeutic Radiologists in Dallas, Texas on October 22, 1980.
- ∗
Resident in Radiation Oncology, Dept. of Radiology.
- †
Professor of Radiology & Director of Radiation Oncology Division, Dept. of Radiology.
- §
Dept. of Psychology, Neurological Institute.
- ∗∗
Associate Professor of Clinical Pediatrics.