Original article
Chromosome analysis of 96 uterine leiomyomas

https://doi.org/10.1016/0165-4608(91)90229-NGet rights and content

Abstract

From September 1989 to May 1990, we attempted cytogenetic analysis on 96 uterine leiomyomas removed from 64 women. Of the 90 tumors in which analysis was successful, 59 had a normal karyotype while 31 had clonal abnormalities. The most common aberration (13 tumors) was 7q−, mostly del(7)(q21.2q31.2); in two tumors with +12 and t(12;14) as the primary abnormalities, the 7q− was obviously a secondary change since it was found only in a subclone. A t(12;14)(q14–15;q23–24) was detected in two tumors, complex aberrations involving both 12q14–15 and 14q23–24 were also present in two, and rearrangements of 12q without concomitant 14q changes were seen in another two myomas. Rearrangements of 6p were present in five tumors, and trisomy 12 was found in two. More than one abnormality could be detected in 17 leiomyomas. Evidence of clonal evolution in the form of subclones was found in eight tumors, all of which were cellular and had histologically detectable mitotic activity. In addition to their clonal complexity, these myomas also frequently exhibited clonal telomeric associations (four tumors) and ring chromosome formation (three tumors; twice affecting chromosome 1). Monosomy 22 occurred as a secondary abnormality in three tumors; it, too, may reflect a preferred pathway in the karyotypic evolution of uterine leiomyomas.

References (37)

  • G Juliusson et al.

    Consistency of chromosomal aberrations in B-lymphocytic leukemia

    Cancer

    (1988)
  • T Pejovic et al.

    Trisomy 12 is a consistent chromosomal aberration in benign ovarian tumors

    Genes Chrom Cancer

    (1990)
  • M Eneroth et al.

    Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2

    Cancer Genet Cytogenet

    (1990)
  • N Mandahl et al.

    Three major cytogenetic subgroups can be identified among chromosomally abnormal lipomas

    Hum Genet

    (1988)
  • N Mandahl et al.

    Characteristic karyotypic anomalies identify subtypes of malignant fibrous histiocytomas

    Genes Chrom Cancer

    (1989)
  • KD Zang

    Cytological and cytogenetical studies on human meningioma

    Cancer Genet Cytogenet

    (1982)
  • G Havel et al.

    Similar chromosomal evolution in a uterine stromomyosarcoma and in one of two leiomyomas from the same patient

    Acta Pathol Microbiol Immunol Scand

    (1989)
  • G Havel et al.

    Cytogenetic relationship between uterine lipoleiomyomas and typical leiomyomas

    Virchows Archiv [B]

    (1989)
  • Cited by (120)

    • Sixteen year-old with leiomyosarcoma in a prior benign myomectomy site

      2019, Gynecologic Oncology Reports
      Citation Excerpt :

      This ULMS had many high-risk features including a large size, necrosis, high pathologic grade, myometrial invasion. The karyotypic aberrations including those of chromosomes 7, 12 and 14 and t(7;13)(p11.2; q11.2) noted in this LM has been previously described (Pandis et al., 1991). There was an unbalanced translocation between the long arms of chromosomes 12 and 14 [resulting in dup (12q)], and a derivative chromosome 15 with interstitial deletion and paracentric inversion of the long arm.

    • Chapter 20 - Uterine Mesenchymal Tumors

      2017, Diagnostic Gynecologic and Obstetric Pathology
    View all citing articles on Scopus

    This work was supported by grants from the Swedish Cancer Society and the Ingabritt and Arne Lundberg's Research Foundation.

    1

    Drs. Pandis and Bardi are on leave from the Papanikolaou Research Center, Hellenic Anticancer Institute, Athens, Greece. Their visit to Sweden was made possible by financial support from the Swedish Institute.

    View full text