Original articleUterine leiomyoma cytogenetics: II. Report of forty cases
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Clinical, pathologic, cytogenetic, and molecular profiling in self-identified black women with uterine leiomyomata
2018, Cancer GeneticsCitation Excerpt :Limited published data exist on the cytogenetic abnormalities associated with fibroids specifically in black women. Multiple separate analyses, using predominantly white or non-population-specific cohorts, have demonstrated that approximately 40% of UL tumors are cytogenetically abnormal (27–29). Thirty-one percent of women in our study had fibroids with cytogenetic abnormalities, while 17.4% of all analyzed tumors were cytogenetically abnormal.
An unusual karyotype in leiomyoma: Case report and literature review
2015, Journal of OrthopaedicsThe genetic heterogeneity of uterine leiomyomata
2006, Obstetrics and Gynecology Clinics of North AmericaUpdates on the cytogenetics and molecular genetics of bone and soft tissue tumors: Leiomyoma
2005, Cancer Genetics and CytogeneticsCitation Excerpt :In contrast to other high-mobility proteins, HMG17 did not seem to play a role in a leiomyoma development with a ring chromosome 1 [169]. Cytogenetic studies in leiomyoma indicated the existence of a subgroup with interstitial deletions of 7q ranging from bands q11.23 to q36 [19,57,59,72,77,170]. Recently, the minimal region on 7q has been narrowed down to less than 500 kb [171].
Differential Binding of an SRF/NK-2/MEF2 Transcription Factor Complex in Normal Versus Neoplastic Smooth Muscle Tissues
2001, Journal of Biological ChemistryCitation Excerpt :The molecular basis for the neoplastic transformation of smooth muscle cells is unknown. Gross chromosomal anomalies have been reported in 40–50% of smooth muscle tumors, with the most common genetic alteration being a deletion of the long arm of chromosome 7 (67-73). Deletion mutations in two of the six collagen type IV subunits have been shown to result in Alport syndrome as well as diffuse leiomyomatosis (74).
Molecular cytogenetic analysis of uterine leiomyoma and leiomyosarcoma by comparative genomic hybridization
2000, Cancer Genetics and Cytogenetics