Cell
MinireviewBraking the cycle
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The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models
2017, Biochemical and Biophysical Research CommunicationsCitation Excerpt :The most important elements that positively regulate the G1 phase are cell cycle proteins (cyclins D1 and E). Cell cycle proteins and cell cycle protein kinases (CDK2, CDK4, and CDK6) are assembled into two types of complexes: cyclin D1/CDK4/CDK6 and cyclin E/CDK2 [34,35]. Studies have shown that CDK is abnormally activated in many tumor tissues and could induce excessive cell proliferation.
Lignans extracted from Vitex negundo possess cytotoxic activity by G2/M phase cell cycle arrest and apoptosis induction
2013, PhytomedicineCitation Excerpt :Eukaryotic cell cycle progression requires sequential activation of cyclin-dependent kinases (Cdks), which is closely related to their association with regulatory cyclins. A complex between Cdk1 and cyclin B1 is critical for cells progressing into mitosis (Hunter 1993). In this regard, we assessed the influence of EVn-50 or VB1 treatment on Cdk1 and cyclin B1 using Western blot analysis.
58-kDa microspherule protein (MSP58) is novel brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway
2012, Journal of Biological ChemistryCadmium-induced alterations of gene expression in human cells
2009, Environmental Toxicology and PharmacologyCitation Excerpt :The gene coding for CARP (cardiac ankyrin repeat protein), known to inhibit DNA synthesis possibly through induction of p21 and subsequent dephosphorylation of Rb (Kanai et al., 2001), was up-regulated [#38/2.6x] (Table 1). Consistent with this, p21 encoding a cyclin-dependent kinase (CDK) inhibitor (Hunter, 1993) was up-regulated [#44/2.5x]. Down-regulation of wip1 was also observed [2-#12/0.38x] (Table 2): its product represses p53 activity through dephosphorylation of p38 mitogen-activated protein kinase (Takekawa et al., 2000).
Role of Genetic Polymorphisms in Breast Cancer
2021, Genetic Polymorphism and Cancer Susceptibility